Getting My ceesdekker.net To Work
Getting My ceesdekker.net To Work
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular kinds with recombination functionality.
[Laughs] ‘It absolutely was unquestionably an awesome hazard! At some time, I had been very well informed that it could go Completely wrong Which I could turn into a lot less productive, but I just ignored that. Curiosity has always been my strongest driving drive. And fortunately all of it worked out.’
2007, initial true-time detection of strand Trade in homologous recombination by RecA; discovery of a minimal persistence duration of finishes of microtubules; and settled the system of biosensing with carbon nanotubes
2015, discovery that condensin is usually a hugely versatile protein structure; and to start with detection of DNA knots working with nanopores
The coiled-coil from the human Rad50 DNA maintenance protein incorporates distinct segments of elevated adaptability
We form microorganisms into kinds that deviate from their organic phenotype. Particularly, I'll exhibit our capacity to form Reside E. coli bacteria into novel styles for instance rectangles, squares, triangles and circles.
He also uncovered time to write down quite a few publications, send out Practically forty thousand tweets and guide a successful exploration group at Delft University of Technological know-how. ‘It doesn’t truly feel like get the job done’, he says. ‘I’m just terribly curious.’
In 1993, being a youthful and eager associate professor at Delft University of Technological know-how, I had originally centered the research efforts of my group on measuring the electrical conductance of only one conducting-polymer molecule. Inside two a long time, we experienced established a device during which an individual wire of the phthalocyaninepolysiloxane polymer was related between two closely spaced metal cees dekker nanoelectrodes.
There was a single dilemma however — we didn't notice any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these types of great conductors, which was rather disappointing. We Therefore broadened our see to try to locate a lot more promising molecules.
Instance (4) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim of the pore is highlighted in pink, and also a 3D rendering on the motion of your DNA rod is exhibited.
2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of 1st logic circuits with carbon nanotube units; and discovery on the molecular framework of DNA mend enzymes with AFM
Let’s very first search back again at this time when you decided to shift your concentrate from superconductivity and nanotubes to biology at the end of the 1990s.
2004, discovery of latest physics in translocation of DNA by means of nanopores; first experimental analyze of ions conduction in nanofluidic channels; 1st electrochemistry with person one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; to start with electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization from the mechanical Attributes of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.